Siem Reap: There is certainly no lack of luxury accomodation in Siem Reap.

Raffles Grand Hotel d'Angkor is perhaps the most iconic one, being opened in 1932 and having hosted luminaries such as Charlie Chaplin, the Clintons and Michelle Obama. The hotel exudes colonial flair and is perfect if you want to stay in somewhere historic while in Siem Reap
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Zannier Phum Baitang, being modelled on Cambodian village, sets itself aside from its rivalries with a stunning 20-acre ground of lush garden and rice paddy fields.
The villas are spacious and many are with their own private pool. If rustic luxury is what you're after then this is the place
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Park Hyatt, another great choice, perhaps oozes more modern aesthetics and is definitely for somebody who wants a stylish & modern hotel that still manages to blend in some ancient Khmer charms in its design.
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For more boutique options consider Aviary Siem Reap or Treeline Urban Resort. Aviary is a sophisticated urban oasis while Treeline Urban distinguishes itself from other hotels with its contemporary art space showcasing emerging and admired Cambodian artists and designers